Dueling quorum sensing systems in Pseudomonas aeruginosa control the production of the Pseudomonas quinolone signal (PQS)

Conversion of the Pseudomonas aeruginosa Quinolone Signal ( PQS ) and Related

The Pseudomonas quinolone signal regulates rhl quorum sensing in Pseudomonas aeruginosa.

The opportunistic pathogen Pseudomonas aeruginosa uses intercellular signals to control the density-dependent expression of many virulence factors. The las and rhl quorum-sensing systems function, respectively, through the autoinducers N-(3-oxododecanoyl)-L-homoserine lactone and N-butyryl-L-homoserine lactone (C(4)-HSL), which are known to positively regulate the transcription of the elastase-...

The Pseudomonas Quinolone Signal (PQS) Balances Life and Death in Pseudomonas aeruginosa Populations

When environmental conditions deteriorate and become inhospitable, generic survival strategies for populations of bacteria may be to enter a dormant state that slows down metabolism, to develop a general tolerance to hostile parameters that characterize the habitat, and to impose a regime to eliminate damaged members. Here, we provide evidence that the pseudomonas quinolone signal (PQS) mediate...

Correction: Dynorphin Activates Quorum Sensing Quinolone Signaling in Pseudomonas aeruginosa

Pseudomonas aeruginosa Olga Zaborina, Francois Lepine, Gaoping Xiao, Vesta Valuckaite, Yimei Chen, Terry Li, Mae Ciancio, Alex Zaborin, Elaine O. Petrof, Jerrold R. Turner, Laurence G. Rahme, Eugene Chang, John C. Alverdy doi: 10.1371/journal.ppat.0030035 In PLoS Pathogens, vol 3, issue 3: One of the authors, Dr. Elaine O. Petrof, was incorrectly listed as Elaine Petroff. This correction note m...

Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability

The 2-alkyl-3-hydroxy-4(1H)-quinolone 2,4-dioxygenase HodC was previously described to cleave the Pseudomonas quinolone signal, PQS, which is exclusively used in the complex quorum sensing (QS) system of Pseudomonas aeruginosa, an opportunistic pathogen employing QS to regulate virulence and biofilm development. Degradation of PQS by exogenous addition of HodC to planktonic cells of P. aerugino...